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KMID : 0385020030190010024
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Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 1 p.24 ~ p.28
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Novel Mutant Establishment Showing Movement Disorder Like Creeping, and Rolling in ENU Mutagenesis
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조재우/Cho, Jae-Woo
조규혁/유제권/임채웅/한상섭/송창우/Cho, Kyu-Hyuk/Yoo, Je Kwon/Lim, Chae-Woong/Han, Sang-Seup/Song, Chang-Woo
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Abstract
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Mutant mice which showed neuromuscular disorder were screened in ENU-mouse-mutagenesis. They were identified at first in the third generation (G_3) after ENU treatment. These mice exhibited abnormal behaviors of ataxia, paralysis, and torsional movement of trunk. They were distinguished from normal littermates at about 2 weeks of age and the mutants died before 3 weeks of age. The body weight of the mutants was 6.22±0.92g but that of normal littermates was 8.04±1.72g (p<0.001) at two weeks of age. Mean number of pups was 5.6 heads and average of weanlings was 4.3 heads. The mutant incidence in the case of mating between carrier and carrier was 26%, 18% and 29% in the G_6, G_7 and G_8, respectively. The sex ration in mutants was 1:1 (male: 32, female: 31) (p>0.05). Therefore we supposed that this mutation was transmitted recessively next generation and the gene was located on autosomal chromosome. This mutant was considered to be an important model animal for studying neuromuscular disorder in view of behavioral characteristics.
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